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Long Term Treatment with Tetradecylthioacetic Acid Improves the Antioxidant Status in Obese Zucker (fa/fa) Rats

[ Vol. 2 , Issue. 2 ]

Author(s):

Hege Wergedahl, Kjetil Berge, Pavol Bohov, Karl-Johan Tronstad, Lise Madsen and Rolf K. Berge   Pages 138 - 145 ( 8 )

Abstract:


Increased oxidative stress was observed in obese Zucker rats. Treatment of obese rats with tetradecylthioacetic acid for 12 weeks increased the H2O2-production, but decreased plasma malondialdehyde, changed the serum fatty acid profile, increased liver fatty acid binding protein mRNA, and lowered serum insulin, thereby enhancing the antioxidant defense system.

Keywords:

Obesity, peroxisome proliferation, antioxidant enzymes, hydrogen peroxide, α-tocopherol, malondialdehyde

Affiliation:

Institute of Medicine, Section of Medical Biochemistry, University of Bergen, Haukeland University Hospital,N-5021 Bergen, Norway.



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