Chakradhara Rao S. Uppugunduri and Marc Ansari Pages 72 - 74 ( 3 )
Major lacunae exist in our understanding of how developmental changes in drug biotransformation influence drug’s exposure and thus its efficacy and toxicity in children. It is not just about smaller weight in children, which modifies the pattern of the drug's exposure. There are developmental, functional changes in organ systems, liver to body mass ratios, and changes in metabolism. Understanding these changes and conducting studies to obtain data on ontogeny of drug metabolizing enzymes is essential for implementation of personalized dosing schedules in the pediatric population.
Children, drug metabolism, enzyme, ontogeny.
Department of Pediatrics, Geneva University Hospitals, Geneva, Switzerland.