Claudio Bruno, Maria Maddalena Cavalluzzi, Alessia Carocci, Alessia Catalano, Carlo Franchini and Giovanni Lentini Pages 52 - 57 ( 6 )
The simultaneous separation and quantification of the analytes within the minimum analysis time and the maximum resolution and efficiency are the main objectives in the development of a capillary electrophoretic method for the determination of solutes. In this paper we describe a specific, sensitive and robust method, using capillary zone electrophoresis with internal standard and UV detection, for the separation and quantification of the anti-arrhythmic drug mexiletine, its main phase I metabolites, and its main nitrogenous degradation product.
Anti-arrhythmics, capillary zone electrophoresis, metabolites, mexiletine.
Dipartimento di Farmacia- Scienze del Farmaco, Università degli Studi di Bari “Aldo Moro”, via Orabona 4, 70126 Bari, Italy.