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Capillary Zone Electrophoresis for Separation and Quantitative Determination of Mexiletine and its Main Phase I Metabolites

[ Vol. 7 , Issue. 1 ]

Author(s):

Claudio Bruno, Maria Maddalena Cavalluzzi, Alessia Carocci, Alessia Catalano, Carlo Franchini and Giovanni Lentini   Pages 52 - 57 ( 6 )

Abstract:


The simultaneous separation and quantification of the analytes within the minimum analysis time and the maximum resolution and efficiency are the main objectives in the development of a capillary electrophoretic method for the determination of solutes. In this paper we describe a specific, sensitive and robust method, using capillary zone electrophoresis with internal standard and UV detection, for the separation and quantification of the anti-arrhythmic drug mexiletine, its main phase I metabolites, and its main nitrogenous degradation product.

Keywords:

Anti-arrhythmics, capillary zone electrophoresis, metabolites, mexiletine.

Affiliation:

Dipartimento di Farmacia- Scienze del Farmaco, Università degli Studi di Bari “Aldo Moro”, via Orabona 4, 70126 Bari, Italy.



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